Boeing-Roundhill Professor of Chemical Engineering
Adjunct Professor of Bioengineering
- B.S., Hua Qiao University, 1985.
- M.S., Nanjing Institute of Chemical Technology, 1988.
- Ph.D., Cornell University, 1993.
- Postdoctoral Fellow, University of California (Berkeley), 1993-1994.
- Research Fellow, California Institute of Technology, 1994-1996.
- Biomolecular Interfaces and Biomaterials
Molecular Understanding, Design and Development of Zwitterionic-based Functional Materials: From Molecular Modeling to Product Development
An important challenge in many applications ranging from biomedical devices to ship hulls is the prevention of nonspecific biomolecule and microorganism attachment onto surfaces. This attachment can be prevented by using a "nonfouling" surface. Our goals are to provide a fundamental understanding of molecular-level nonfouling mechanisms and to develop biocompatible and environmentally benign nonfouling materials using molecular design principles.
Over the last few years, we have demonstrated that zwitterionic and mixed charge materials are unique, effective and robust for a wide range of applications. In addition to their excellent nonfouling properties, zwitterionic carboxybetaine-based materials have abundant functional groups for ligand immobilization. Superhydrophilic zwitterionic materials are fully compatible to biomolecules, cells and tissues. Cationic and hydrolysable zwitterionic ester precursors have self-sterilizing capabilities and other unique properties. Our results show that the strong hydration of zwitterionic materials is responsible for their excellent nonfouling properties.
We take a unique holistic approach to our research by performing both simulations and experiments. Novel materials are designed, synthesized, tested and improved upon all within our group. This collaborative approach allows us to always strive towards understanding nature at all levels. Creative ideas and innovative technologies are always our emphasis.
Selected Recent Publications
- L. Mi and S. Jiang, Integrated Antimicrobial and Nonfouling Zwitterionic Polymers, Angewandte Chemie (Mini Review), 53, 1746 (2014).
- W. Yang, S. Liu, T. Bai, A.J. Keefe, L. Zhang, J.R. Ella-Menye, Y. Li, and S. Jiang, Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production, Nano Today, 9, 10, 2014.
- T. Bai, S. Liu, F. Sun, A. Sinclair, L. Zhang, Q. Shao and S. Jiang, Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions, Biomaterials, 35, 3926 (2014).
- L. Zhang, Z. Cao, L. Carr, T. Bai, J.R. Ella-Menye, C. Irvin, B.D. Ratner and S. Jiang, Zwitterionic Hydrogels Implanted in Mice Resist the Foreign-body Reaction, Nature Biotechnology, 31, 553 (2013).
- Keefe, A., Jiang, S. Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity. Nature Chemistry 2012, 4(1), pp. 60-64.
- W. Yang, L.R. Carr, T, Bai, A, J. Keefe, J. Xu, H, Xue, C. Irvin, S. Chen, J. Wang and S. Jiang, The Effect of Lightly Crosslinked Poly(carboxybetaine) Hydrogel Coating on the Performance of Sensors in Whole Blood, Biomaterials, 33, 7945 (2012).
- Jiang, S.Y., Cao, Z.Q. Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications (Invited Perspective Article), Advanced Materials 2010, 22(9), pp. 920-932.
- Z. Q. Cao,Z.Q., Yu, Q., Xue, H., Cheng, G., Jiang, S.Y. Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks. Angew. Chem. Int. Ed. 2010, 49(22), pp. 3771-3776.
- S. Chen, J. Zheng, L. Li, and S. Jiang, Strong Resistance of Phosphorylcholine Self-Assembled Monolayers to Protein Adsorption: Insights into Nonfouling Properties of Zwitterionic Materials, Journal of the American Chemical Society, 127, 14473 (2005).
- L. Li, S. Chen, J. Zheng, B. D. Ratner, and S. Jiang, Protein Adsorption on Oligo(ethylene glycol)-Terminated Alkanethiolate Self-Assembled Monolayers: The Molecular Basis for Nonfouling Behavior, Journal of Physical Chemistry B, 109, 2934 (2005).