Boeing-Roundhill Professor of Chemical Engineering and Adjunct Professor of Bioengineering
Office: 243 Benson
Fax: 206-685-3451 or 206-543-3778
Website: Jiang Group Website
- B.S., Hua Qiao University, 1985.
- M.S., Nanjing Institute of Chemical Technology, 1988.
- Ph.D., Cornell University, 1993.
- Postdoctoral Fellow, University of California (Berkeley), 1993-1994.
- Research Fellow, California Institute of Technology, 1994-1996.
- Biomolecular Interfaces and Biomaterials
Molecular Understanding, Design and Development of Zwitterionic-based Functional Materials: From Molecular Modeling to Product Development
An important challenge in many applications ranging from biomedical devices to ship hulls is the prevention of nonspecific biomolecule and microorganism attachment onto surfaces. This attachment can be prevented by using a "nonfouling" surface. Our goals are to provide a fundamental understanding of molecular-level nonfouling mechanisms and to develop biocompatible and environmentally benign nonfouling materials using molecular design principles.
Over the last few years, we have demonstrated that zwitterionic and mixed charge materials are unique, effective and robust for a wide range of applications. In addition to their excellent nonfouling properties, zwitterionic carboxybetaine-based materials have abundant functional groups for ligand immobilization. Superhydrophilic zwitterionic materials are fully compatible to biomolecules, cells and tissues. Cationic and hydrolysable zwitterionic ester precursors have self-sterilizing capabilities and other unique properties. Our results show that the strong hydration of zwitterionic materials is responsible for their excellent nonfouling properties.
We take a unique holistic approach to our research by performing both simulations and experiments. Novel materials are designed, synthesized, tested and improved upon all within our group. This collaborative approach allows us to always strive towards understanding nature at all levels. Creative ideas and innovative technologies are always our emphasis.
Selected Recent Publications
- Keefe, A., Jiang, S. Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity. Nature Chemistry 2012, 4(1), pp. 60-64.
- Cao, Z., Jiang, S. Super-hydrophilic Zwitterionic Poly(carboxybetaine) and Amphiphilic Non-ionic Poly(ethylene Glycol) for Stealth Nanoparticles. Nano Today 2012, in press, 2012.
- Nowinski, A.K., Sun, F., White, A.D., Keefe, A.J., Jiang, S. Sequence, Structure, and Function of Peptide Self-assembled Monolayers. Journal of the American Chemical Society 2012, 134(13), pp. 6000-6005.
- Cao, Z.Q., Mi, L., Mendiola, J., Ella-Menye, J.R., Zhang, L., Xue, H., Jiang, S. Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria. Angewandte Chemie International Edition 2012, 51(11), pp. 2602-2605.
- Huang, C.J., Brault, N.D., Li, Y.T., Yu, Q., Jiang, S.Y. Controlled Hierarchical Architecture in Surface-initiated Zwitterionic Polymer Brushes with Structurally Regulated Functionalities. Advanced Materials 2012, 24(14), pp. 1834-1837.
- Mi, L., Giarmarco, M.M., Shao, Q., Jiang, S.Y. Divalent Cation-mediated Polysaccharide Interactions with Zwitterionic Surfaces. Biomaterials 2012, 33(7), 2001-2006.
- Carr, L.R., Krause, J.E., Ella-Menye, J.R., Jiang, S.Y. Single Nonfouling Hydrogels with Mechanical and Chemical Functionality Gradients. Biomaterials 2011, 32(33), pp. 8456-8461.
- Zhang, L., Xue, H., Cao, Z., Keefe, A., Wang, J., Jiang, S.Y. Multifunctional and Degradable Zwitterionic Nanogels for Targeted Delivery, Enhanced MR Imaging, Reduction-sensitive Drug Release, and Renal Clearance. Biomaterials 2011, 32(20), pp. 4604-4608.
- Yang, W., Xue, H., Carr, L.R., Wang, J., Jiang, S. Zwitterionic Poly(carboxybetaine) Hydrogels for Glucose Biosensors in Complex Media. Biosensors and Bioeletronics 2011, 26(5), pp. 2454-2459.
- Jiang, S.Y., Cao, Z.Q. Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications (Invited Perspective Article), Advanced Materials 2010, 22(9), pp. 920-932.
- Z. Q. Cao,Z.Q., Yu, Q., Xue, H., Cheng, G., Jiang, S.Y. Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks. Angew. Chem. Int. Ed. 2010, 49(22), pp. 3771-3776.