ChemE 491 - Controlled Release Systems - Principles and Applications

Course Description

Credits: 3.  Mechanisms or controlled release of active agents and the development of useful systems for this purpose.  Release mechanisms include diffusive, convective, or erosive driving forces. Applications to the biomedical agricultural, forestry, and oceanography fields. Some special case studies covered in detail. Offered: jointly with BIOEN 491; even years; W.

Designation

Prerequisites

Organic chemistry, physical chemistry, transport phenomena.

Textbook

Drug Delivery:  Engineering Principles for Drug Therapy. Mark Saltzman, Oxford University Press, 2001 ISBN: 0195085892.

Course Objectives

This course introduces upper division undergraduates in Bioengineering, Chemical Engineering and Chemistry to principles used in designing controlled drug delivery systems.  Students will learn basic principles in pharmacology, drug transport, and biomaterials used in drug delivery.  The students apply this knowledge in a final team-based design project.

1. Basic pharmacology (PK/PD)
2. Diffusion in biological systems
3. Drug permeation and transport
4. Biomaterials and modulation of drug activity 
5. Drug administration methods
6. Macromolecule drug delivery
7. Targeted drug delivery
8. Intellectual property issues in drug delivery

Engineering
Design content

(a)   An ability to apply knowledge of mathematics, science, and engineering.

(c) The graduate should have an ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability, and sustainability.

(e)   An ability to identify, formulate, and solve engineering problems.

(g) An ability to communicate effectively.

(j)    A knowledge of contemporary issues related to safety and the environment.