Chemical Engineering
 

ChemE 490 - Engineering Materials for Biomedical Applications

Course Description

Credits: 3.  Combined application of the principles of physical chemistry, biochemistry, materials engineering, mass transfer, and fluid mechanics to biomedical problems. Case studies include considerations of the selection of materials, the design and the operation of instruments, components of, or entire, artificial organs (heart, kidney, lung) and artificial structural elements (bone, teeth, skin), all for use in contact with body fluids. Offered: jointly with BIOEN 490; W.

Designation

 Elective.

Prerequisites

Cell biology, Organic chemistry, Physical chemistry.

Textbook

Biomaterials Science, 2nd Edition (2004).  Edited by B. D. Ratner, A. S. Hoffman, F. Schoen, and J. Lemons.  ISBN 0125824637 2004.  Elsevier Academic Press.

Course Objectives

The objectives of the course are to provide the students with:

  1. Knowledge of chemical and mechanical properties of materials currently used in devices used in contact with the body, their large impact on human health,  and the major bodily reactions to the devices.
    Assessed by: exams.
  2. The ability to apply principles in mathematics, science and engineering to the design and evaluation of biomaterials and biomedical devices.
    3. Assessed by: failure mechanisms presentation, term paper, and exams.
  3. An overview of current limitations of biomedical devices and strategies being studied in both academia and industry to address these limitations.
    4. Assessed by: exams, presentation on biomaterials in current devices, term paper.
  4. The opportunity to present their findings of biomaterials used in current devices and their analysis of design limitations of current devices in two oral presentations to their peers and to write a proposal to overcome one or more design limitations of current devices in a written document.
    5. Assessed by: biomaterials in current devices and failure of device presentation, term paper.

Topics Covered

 History; relevance and impact; Materials in selected clinical devices (presentations by students in class); Metallic biomaterials: chemical compositions, corrosion/fretting, mechanical properties, osteoinductivity, bone cements; Bioceramics and bioglasses and carbons; natural biomaterials; special terminology; Polymeric biomaterials, chemistry and properties, including polyurethanes and plasma deposited polymers; biomaterials for tissue engineering; biological reactions to implants: blood clotting; foreign body reaction; Failure of devices (presentations by students in class); Surface analysis of biomaterials; Biomaterials in drug delivery; Stents, blood compatibility testing, heparinized surfaces; protein adsorption,  foreign body reaction; toxicological testing; device related infection. Biological correlations.
Class schedule:
 Lectures: 1hr 20 min/lecture, meet twice a week
Contributions of Course to meeting the Professional Component:

Engineering
Design content

Relationship of Course to Program Outcomes:

(a)   An ability to apply knowledge of mathematics, science, and engineering.

(c) The graduate should have an ability to design a system, component, or process to meet desired needs within realistic constraints such as economic, environmental, social, political, ethical, health and safety, manufacturability, and sustainability.

(f) An understanding of professional and ethical responsibility.

(h)  The broad education necessary to understand the impact of engineering solutions in a global, economic, environmental, and societal context.

(j)    A knowledge of contemporary issues related to safety and the environment.
Prepared by:

Thomas A. Horbett , Date: May 17, 2007